- Study Institution Summary Date
- Acute Toxicity LD50 Study Medical University There were no mortality and no any adverse events observed in gold-treated mice during the study period. NOAEL: 3600mg/kg Apr. 2001
- Sub Acute Toxicity Study Medical University There were no mortality and no any adverse events observed in gold-treated mice during the study period. Mar. 2002
- Gold ISO Closed Patch Sensitization Study NAMSA Under the conditions of this study, the test article showed no evidence of causing delayed dermal contact sensitization. Sep 2003
- Gold ISO irritation Study NAMSA Under the conditions of this study, no erythema and no edema were observed on the skin. Aug 2003
- Ames Test GLP compliant animal laboratory；AAALAC certified GOLD did not cause a positive response under the tested condition both in the presence and absence of metabolic activation and was concluded to be negative. Mar 2004
- Micronucleus assay in mice GLP compliant animal laboratory；AAALAC certified Micronucleus assay in mice indicated gold did not cause a positive response in the test system and concluded to be negative in mouse peripheral blood micronucleus assay. Mar 2004
- In vitro chromosome aberration assay for gold in Chinese Hamster Ovary cells GLP compliant animal laboratory；AAALAC certified Gold did not significantly induce structural chromosome aberration, and is concluded to be negative in the in vitro chromosome aberration assay in Chinese hamster ovary cells. Mar 2005
- Acute Oral Toxicity Study – 14-day in mice GLP compliant animal laboratory；AAALAC certified There were no mortality and no any adverse events observed in gold-treated mice during the 14-day study period. Feb 2004
- Acute Oral Toxicity Study – 14-day in rat GLP compliant animal laboratory；AAALAC certified There were no mortality and no any adverse events observed in gold-treated rats during the 14-day study period. Mar 2004
- Sub Acute Oral Toxicity Study in rat– 28-day in rat Government-funded research center There were no mortality and no any adverse events observed in gold-treated rats during the 28-day study period. Aug 2005
- Sub Acute Oral Toxicity Study in rat– 90-day in rat Government-funded research center There were no mortality and no any adverse events observed in gold-treated rats during the 90-day study period. Dec 2006